What happens to the brain after years of excessive smoking of weed?

Michael Backes, Cannabis Pharmacy, Author at Blackbridge Group LLC (2014-present)

I've worked with a huge number of cannabis clients in the course of the most recent decade. I've seen people that consistently expend well over a gram of THC consistently. 

This is what occurs with overwhelming cannabis clients, which I consider every day utilization of in excess of 150 milligrams of THC for a period more noteworthy than three months, say three joints per day or 10 bong tears for every day. I would say this utilization design speaks to around 15 percent of general cannabis clients. 

The substantial client will build up a noteworthy resistance to the impacts of cannabis that every so often results in their day by day admission of THC heightening upwards to a gram daily or more. Be that as it may, some substantial clients don't see their cannabis admission increment drastically, while resistance to its belongings will be observable. The resistance to THC's belongings are caused by the specific downregulation of CB1 cannabinoid receptors in a few areas of the cerebrum, which implies the mind's CB1 receptor thickness in some mind tissue is altogether decreased. 

At the point when this downregulation happens in the mind's hippocampus, mellow issues emerge with putting away and reviewing recollections. Numerous clients adjust their practices to these memory issues, so they scarcely see, however their companions may. Adapting new things can take longer and constancy can be all the more difficult. So, there are some advanced, overwhelming cannabis clients. 

Overwhelming clients that have quit utilizing cannabis or impressively decreased their day by day allow normally note being all the more composed with better memory work. 


A significant number of the subjective effects of high-THC cannabis can be decreased by at the same time devouring an equivalent measure of CBD. Additionally, numerous clients who add CBD to their substantial cannabis routine watch a noteworthy decrease in their longing to expend a lot of high-THC cannabis (and liquor and tobacco.) An odd thing I've seen is that overwhelming clients that change to Type II cannabis (which produces both THC and CBD) rapidly lean toward it over Type I cannabis (the considerably more typical high-THC cannabis that produces no CBD.)